MiNuSPain
WE ARE
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Sciatic nerve section in electron microscopy showing C fibers.

NEUROPATHIC PAIN?
WHAT IS
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Dorsal root ganglion: sensory neurons peptidergic
in green and not peptidergic in red.

NEUROPATHIC PAIN
WHAT CAUSES
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Dorsal root ganglion: satellite cells surrounding neurons

“Fibromyalgia: Why does my whole body hurts ?”, is the first informative capsule on #Fibromyalgia prepared jointly by the Millennium Nucleus #MiNuSPain and the UC Christus Health Network.

Enter to our Social Networks and YouTube channel to learn more about this disease.

MILLENNIUM NUCLEUS FOR THE STUDY OF PAIN

We are a scientific consortium dedicated to investigate in translational neuroscience of pain. We aim at training advanced human capital in scientific and clinical area.

Our Millennium Nucleus MiNuSPain includes five research laboratories whose competences range from cutting-edge biomedical research to clinical studies. MiNusPain collaborations are reflected in associative projects, publications, international conferences and co-supervision of trainees.

Our work has a translational approach from the bedside to the bench and back, a concept that illustrates the path along which our lines of research progress collaboratively, ranging from biomedical science to patients. We are focused on investigating key molecular determinants involved in neuropathic pain. In particular, we will focus on the study of cellular and molecular mechanisms in preclinical and clinical models.

C fibers crossing from the dermis to the epidermis.

WHAT IS NEUROPHATIC PAIN?

It is defined as pain caused by an illness that affects the somatosensory nervous system.

Neuropathic pain affects about 7 to 10% of the world population. Neuropathic pain is disabling and produces a great socioeconomic cost. Therefore, it has become a priority public health problem.

Currently, treatments for neuropathic pain are poorly tolerated and their efficacy is poor. The opioid epidemic has shown us that the effect of long term use of these medications can be a real problem. A better understanding of the cellular and molecular bases of neuropathic pain will provide fundamental keys to recognize new pharmacological targets for treatment.

Explant of rat´s sensory neuron. Credits: Paula Díaz

WHAT CAUSES NEUROPATHIC PAIN?

It is caused by a lesion to any part of the somatosensory system, thereby it can be peripheral or central. Important causes of peripheral neuropathic pain are lumbar radiculopathy (nerve root compression), postherpetic neuralgia (persistent pain after a herpes episode), diabetic neuropathy, HIV-related neuropathy and chronic postsurgical pain, among others.

Central neuropathic pain can appear after a cerebrovascular disease,  a spinal cord lesion, multiple sclerosis or after other neurological and metabolic conditions.

The diagnosis of neuropathic pain is made when a patient presents pain together with signs of injury in the nervous system, such as altered sensibility, or pain response after subtle contact.

DRG after axonal damage. Kv1.6 channels are seen in green and sensory neurons in red.

OUR RESEARCHERS

Dra. Margarita Calvo

Dra. Margarita Calvo

Director of the Millennium Nucleus MiNuSPain

Medical doctor from Pontificia Universidad Católica de Chile, Associate Professor at the Faculty of Biological Sciences of the Pontificia Universidad Católica de Chile and Physician in the Pain Unit at the UC Christus University Hospital (Chile).

Dr. Elias Utreras

Dr. Elias Utreras

Alternate Director of the Millennium Nucleus MiNuSPain

Assistant Professor at the Department of Biology, Faculty of Sciences, Universidad de Chile (Santiago, Chile)

Dr. Claudio Coddou

Dr. Claudio Coddou

Associate Researcher at the Millennium Nucleus MiNuSPain

Associate Professor at the Department of Biomedical Sciences, Faculty of Medicine, Catholic University of the North (Coquimbo Chile)

Dr. Rodolfo Madrid

Dr. Rodolfo Madrid

Associate Researcher at the Millennium Nucleus MiNuSPain

Associate Professor at Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile (Santiago, Chile).

Dr. Gonzalo Yévenes

Dr. Gonzalo Yévenes

Associate Researcher at the Millennium Nucleus MiNuSPain

Associate Professor at Department of Physiology, Faculty of Biological Science, University of Concepcion (Concepcion, Chile)

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